Search results for "Cytotoxic T-lymphocyte antigen 4"

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Is there any place for PD-1/CTLA-4 inhibitors combination in the first-line treatment of advanced NSCLC?—A trial-level meta-analysis in PD-L1 selecte…

2021

BACKGROUND: The advent of immuno-oncology (IO) represented a breakthrough in non-small cell lung cancer (NSCLC) therapy over the last few years. However, establishing the optimal therapeutic options among programmed death-ligand 1 (PD-L1) selected subgroups still addresses an unmet need in the clinical setting. METHODS: We performed a systematic review and finally included eleven first-line randomized controlled trials to compare efficacy and safety outcomes among first-line IO treatment strategies versus standard platinum-based chemotherapy (CT) according to PD-L1 expression level (<1%, 1–49%, ≥50%). Pooled hazard ratios (HRs) and risk ratios (RRs) for progression-free survival (PFS), over…

Oncologymedicine.medical_specialtyprogrammed death-1/cytotoxic T-lymphocyte antigen 4 inhibitors (PD-1/CTLA-4 inhibitors)combined modality therapybusiness.industryHazard ratioCombined modality therapy; Immunotherapy; Meta-analysis; Non-small cell lung cancer (NSCLC); Programmed death-1/cytotoxic T-lymphocyte antigen 4 inhibitors (PD-1/CTLA-4 inhibitors)non-small cell lung cancer (NSCLC)Non-small cell lung cancer (NSCLC)medicine.diseaselaw.inventionDiscontinuationmeta-analysisOncologyRandomized controlled triallawRelative riskInternal medicineMeta-analysisMedicineOriginal ArticleimmunotherapybusinessLung cancerAdverse effect
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Monoclonal antibodies for the treatment of non-haematological tumours: update of an expanding scenario.

2015

Abstract: Introduction: The identification of cell membrane-bound molecules with a relevant role in cancer cell survival prompted the development of moAbs to block the related pathways. In the last few years, the number of approved moAbs for cancer treatment has constantly increased. Many of these drugs significantly improved the survival outcomes in patients with solid tumours. Areas covered: In this review, all the FDA-approved moAbs in solid tumours have been described. This is an update of moAbs available for cancer treatment nowadays in comparison with the moAbs approved until few years ago. The moAbs under development are also discussed here. Expert opinion: The research on cancer ant…

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